Head to Head
| England League Cup Women | 2024/10/03 18:00 | Southampton Women v London City Lionesses Women | W | 0-1 |
| England Championship Women | 2024/04/21 13:00 | Southampton Women v London City Lionesses Women | L | 3-1 |
| England Championship Women | 2023/10/22 12:00 | London City Lionesses Women v Southampton Women | W | 1-0 |
| England Championship Women | 2023/04/16 13:00 | Southampton Women v London City Lionesses Women | L | 1-0 |
| England Championship Women | 2022/12/04 14:00 | London City Lionesses Women v Southampton Women | D | 1-1 |
Home History
| England League Cup Women | 2024/12/11 19:00 | Portsmouth Women v London City Lionesses Women | W | 2-5 |
| England FA Cup Women | 2024/12/08 14:00 | London City Lionesses Women v Gwalia United Women | W | 4-0 |
| England League Cup Women | 2024/11/24 14:00 | London City Lionesses Women v West Ham Women | L | 1-4 |
| England Championship Women | 2024/11/17 12:00 | Durham Women v London City Lionesses Women | L | 3-2 |
| England Championship Women | 2024/11/10 14:00 | London City Lionesses Women v Birmingham Women | L | 1-2 |
| England Championship Women | 2024/11/02 14:00 | Sheff Utd Women v London City Lionesses Women | W | 0-1 |
| England Championship Women | 2024/10/13 13:00 | London City Lionesses Women v Charlton Women | W | 2-0 |
| England Championship Women | 2024/10/06 13:00 | London City Lionesses Women v Portsmouth Women | W | 5-1 |
Away History
| England League Cup Women | 2024/12/11 19:00 | West Ham Women v Southampton Women | L | 3-0 |
| England League Cup Women | 2024/11/24 14:00 | Portsmouth Women v Southampton Women | W | 0-4 |
| England Championship Women | 2024/11/17 14:00 | Newcastle United Women v Southampton Women | D | 1-1 |
| England Championship Women | 2024/11/10 12:00 | Southampton Women v Durham Women | D | 1-1 |
| England Championship Women | 2024/11/03 14:00 | Charlton Women v Southampton Women | W | 0-1 |
| England Championship Women | 2024/10/20 13:00 | Southampton Women v Birmingham Women | L | 0-2 |
| England Championship Women | 2024/10/13 13:00 | Portsmouth Women v Southampton Women | W | 0-5 |
| England League Cup Women | 2024/10/03 18:00 | Southampton Women v London City Lionesses Women | L | 0-1 |