Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2023/09/01 00:00 | Missouri Southern Lions v NW Missouri State | L | 24-31 |
| NCAAF | 2022/11/05 18:30 | NW Missouri State v Missouri Southern Lions | L | 27-5 |
| NCAAF | 2021/11/06 19:00 | Missouri Southern Lions v NW Missouri State | L | 7-49 |
| NCAAF | 2019/09/21 23:00 | Missouri Southern Lions v NW Missouri State | L | 34-66 |
| NCAAF | 2018/09/15 18:30 | NW Missouri State v Missouri Southern Lions | L | 63-0 |
| NCAAF | 2024/09/14 23:00 | Missouri Western Griffons v Missouri Southern Lions | L | 35-27 |
| NCAAF | 2024/09/08 00:00 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 17-42 |
| NCAAF | 2024/08/30 00:00 | Midwestern State University Mustangs v Missouri Southern Lions | L | 18-11 |
| NCAAF | 2023/11/11 20:00 | Missouri Southern Lions v Missouri Western Griffons | W | 47-41 |
| NCAAF | 2023/11/04 18:00 | Emporia State v Missouri Southern Lions | L | 63-28 |
| NCAAF | 2023/10/28 19:00 | Missouri Southern Lions v Central Missouri Mules | L | 21-42 |
| NCAAF | 2023/10/21 19:00 | Blue Tigers v Missouri Southern Lions | W | 5-63 |
| NCAAF | 2023/10/14 19:00 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 21-31 |
| NCAAF | 2024/09/14 23:00 | NW Missouri State v Fort Hays State University Tigers | W | 32-20 |
| NCAAF | 2024/09/08 00:00 | Nebraska Kearney v NW Missouri State | L | 21-14 |
| NCAAF | 2024/08/29 23:00 | NW Missouri State v Minnesota State Mankato Mavericks | L | 22-36 |
| NCAAF | 2023/11/11 19:30 | NW Missouri State v Nebraska Kearney | W | 56-7 |
| NCAAF | 2023/11/04 19:00 | Northeastern State Riverhawks v NW Missouri State | W | 0-52 |
| NCAAF | 2023/10/28 18:00 | Washburn Ichabods Football v NW Missouri State | W | 31-52 |
| NCAAF | 2023/10/21 19:00 | NW Missouri State v Pittsburgh State Gorillas | L | 7-28 |
| NCAAF | 2023/10/14 18:00 | Missouri Western Griffons v NW Missouri State | W | 23-27 |