Stadium: Blackstock Stadium Round: 1
| NCAAF | 2023/09/02 23:00 | Rose Hulman Engineers v Depauw Tigers | W | 21-33 |
| NCAAF | 2022/09/03 17:00 | Depauw Tigers v Rose Hulman Engineers | W | 17-14 |
| NCAAF | 2021/11/20 17:00 | Depauw Tigers v Rose Hulman Engineers | W | 26-21 |
| NCAAF | 2023/11/18 17:00 | Alma College Scots v Depauw Tigers | L | 32-17 |
| NCAAF | 2023/11/11 18:07 | Wabash Little Giants v Depauw Tigers | W | 30-33 |
| NCAAF | 2023/10/28 16:00 | Depauw Tigers v Kenyon Lords | W | 58-7 |
| NCAAF | 2023/10/21 18:00 | Wittenberg Tigers v Depauw Tigers | W | 35-41 |
| NCAAF | 2023/10/14 18:00 | Wooster Scots v Depauw Tigers | W | 7-53 |
| NCAAF | 2023/10/07 17:00 | Depauw Tigers v Denison Big Red | W | 17-6 |
| NCAAF | 2023/09/30 17:00 | Oberlin Yeomen v Depauw Tigers | W | 7-66 |
| NCAAF | 2023/09/23 17:00 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 28-7 |
| NCAAF | 2023/11/11 18:30 | Rose Hulman Engineers v Mount St. Joseph Lions | L | 20-68 |
| NCAAF | 2023/11/04 17:30 | Defiance Yellow Jackets v Rose Hulman Engineers | W | 54-78 |
| NCAAF | 2023/10/28 18:00 | Rose Hulman Engineers v Hanover | W | 44-39 |
| NCAAF | 2023/10/21 17:30 | Franklin College Grizzlies v Rose Hulman Engineers | W | 35-50 |
| NCAAF | 2023/10/14 17:30 | Rose Hulman Engineers v Bluffton Beavers | W | 52-28 |
| NCAAF | 2023/10/07 17:30 | Manchester Spartans v Rose Hulman Engineers | W | 7-44 |
| NCAAF | 2023/09/30 18:00 | Rose Hulman Engineers v Anderson Ravens | W | 64-3 |
| NCAAF | 2023/09/16 16:00 | Albion Britons v Rose Hulman Engineers | L | 48-19 |