Head to Head
| England League 1 | 2024/10/19 14:00 | Northampton v Leyton Orient | L | 1-0 |
| England League 1 | 2024/02/13 19:45 | Leyton Orient v Northampton | W | 4-3 |
| England League 1 | 2023/10/24 18:45 | Northampton v Leyton Orient | D | 2-2 |
| England League 2 | 2023/01/02 15:00 | Northampton v Leyton Orient | L | 1-0 |
| England League 2 | 2022/10/15 14:00 | Leyton Orient v Northampton | D | 0-0 |
| England League 2 | 2022/04/23 14:00 | Leyton Orient v Northampton | L | 2-4 |
| England League 2 | 2021/11/27 15:00 | Northampton v Leyton Orient | L | 1-0 |
| Club Friendly List | 2020/08/22 12:00 | Northampton v Leyton Orient | L | 1-0 |
Home History
| England League 1 | 2025/01/04 15:00 | Leyton Orient v Shrewsbury | W | 1-0 |
| England League 1 | 2025/01/01 15:00 | Bristol Rovers v Leyton Orient | W | 2-3 |
| England League 1 | 2024/12/29 15:00 | Leyton Orient v Cambridge Utd | W | 2-0 |
| England League 1 | 2024/12/26 13:00 | Leyton Orient v Crawley Town | W | 3-0 |
| England League 1 | 2024/12/21 15:00 | Barnsley v Leyton Orient | W | 0-4 |
| England League 1 | 2024/12/14 12:30 | Leyton Orient v Burton Albion | D | 0-0 |
| England EFL Trophy | 2024/12/10 19:00 | Charlton v Leyton Orient | W | 0-2 |
| England League 1 | 2024/12/07 12:30 | Wigan v Leyton Orient | W | 0-2 |
Away History
| England League 1 | 2025/01/04 12:30 | Burton Albion v Northampton | W | 0-1 |
| England League 1 | 2025/01/01 15:00 | Northampton v Stevenage | D | 0-0 |
| England League 1 | 2024/12/29 15:00 | Shrewsbury v Northampton | D | 1-1 |
| England League 1 | 2024/12/26 15:00 | Reading v Northampton | L | 4-1 |
| England League 1 | 2024/12/21 15:00 | Northampton v Charlton | L | 0-5 |
| England EFL Trophy | 2024/12/17 19:00 | Peterborough v Northampton | L | 3-0 |
| England League 1 | 2024/12/14 15:00 | Rotherham v Northampton | L | 3-0 |
| England League 1 | 2024/12/09 20:00 | Northampton v Peterborough | W | 2-1 |