Stadium: Jack Britt Memorial Stadium Round: 1
| NCAAF | 2023/10/07 17:00 | Ohio Dominican Panthers v Lake Erie | L | 41-17 |
| NCAAF | 2022/10/08 16:00 | Lake Erie v Ohio Dominican Panthers | L | 7-38 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | L | 31-0 |
| NCAAF | 2019/11/09 18:00 | Ohio Dominican Panthers v Lake Erie | L | 49-10 |
| NCAAF | 2018/11/10 17:00 | Lake Erie v Ohio Dominican Panthers | L | 6-62 |
| NCAAF | 2024/11/02 17:00 | Lake Erie v Ashland Eagles | L | 14-41 |
| NCAAF | 2024/10/26 16:00 | Tiffin Dragons v Lake Erie | L | 63-10 |
| NCAAF | 2024/10/19 18:30 | Lake Erie v Hillsdale Chargers | L | 10-28 |
| NCAAF | 2024/10/12 21:00 | Kentucky Wesleyan v Lake Erie | W | 23-29 |
| NCAAF | 2024/10/05 16:00 | Walsh U. Cavaliers v Lake Erie | L | 63-34 |
| NCAAF | 2024/09/28 22:00 | Lake Erie v Northwood Timberwolves | L | 20-55 |
| NCAAF | 2024/09/21 16:00 | Findlay Oilers v Lake Erie | L | 42-6 |
| NCAAF | 2024/09/14 18:30 | Lake Erie v Post University Eagles | W | 28-27 |
| NCAAF | 2024/11/02 17:00 | Northwood Timberwolves v Ohio Dominican Panthers | L | 37-10 |
| NCAAF | 2024/10/26 16:00 | Ohio Dominican Panthers v Walsh U. Cavaliers | W | 16-7 |
| NCAAF | 2024/10/19 16:00 | Ohio Dominican Panthers v Findlay Oilers | L | 10-26 |
| NCAAF | 2024/10/12 20:00 | Tiffin Dragons v Ohio Dominican Panthers | L | 31-13 |
| NCAAF | 2024/10/05 17:00 | Ashland Eagles v Ohio Dominican Panthers | L | 26-6 |
| NCAAF | 2024/09/28 17:00 | Ohio Dominican Panthers v Kentucky Wesleyan | W | 38-7 |
| NCAAF | 2024/09/21 17:00 | Ohio Dominican Panthers v Thomas More Saints | L | 0-6 |
| NCAAF | 2024/09/14 22:00 | Winston-Salem State v Ohio Dominican Panthers | L | 19-13 |