[26] Serena Williams 6-4,6-3 Karolina Pliskova [8] 2018-09-04 23:10
Stadium: Arthur Ashe Stadium Round: 27 Ground: Hardcourt outdoor
Head to Head
| US Open 2016 Women | 2016/09/08 23:00 | Serena Williams v Karolina Pliskova | 2-6,6-7 |
Home History
| US Open Women | 2018/09/02 19:45 | Kaia Kanepi v Serena Williams | 0-6,6-4,3-6 |
| US Open Women | 2018/09/01 00:00 | Serena Williams v Venus Williams | 6-1,6-2 |
| US Open Women | 2018/08/29 23:05 | Serena Williams v Carina Witthoeft | 6-2,6-2 |
| US Open Women | 2018/08/28 00:00 | Serena Williams v Magda Linette | 6-4,6-0 |
| WTA Cincinnati | 2018/08/15 00:30 | Petra Kvitova v Serena Williams | 6-3,2-6,6-3 |
| WTA Cincinnati | 2018/08/13 23:00 | Daria Saville v Serena Williams | 1-6,2-6 |
| WTA San Jose | 2018/08/01 02:00 | Serena Williams v Johanna Konta | 1-6,0-6 |
| Wimbledon Women | 2018/07/14 15:10 | Angelique Kerber v Serena Williams | 6-3,6-3 |
Away History
| US Open Women | 2018/09/02 18:00 | Ashleigh Barty v Karolina Pliskova | 4-6,4-6 |
| US Open Women | 2018/09/01 02:10 | Sofia Kenin v Karolina Pliskova | 4-6,6-7 |
| US Open Women | 2018/08/29 18:50 | Ana Bogdan v Karolina Pliskova | 2-6,3-6 |
| US Open Women | 2018/08/27 19:05 | Zarina Diyas v Karolina Pliskova | 4-6,6-7 |
| WTA New Haven | 2018/08/20 17:05 | Karolina Pliskova v Ekaterina Makarova | 1-6,3-6 |
| WTA Cincinnati | 2018/08/15 15:00 | Karolina Pliskova v Aryna Sabalenka | 6-2,3-6,5-7 |
| WTA Cincinnati | 2018/08/14 17:15 | Karolina Pliskova v Agnieszka Radwanska | 6-3,6-3 |
| WTA Montreal | 2018/08/08 16:40 | Karolina Pliskova v Kiki Bertens | 2-6,2-6 |