Louisville 3-27 Virginia 2018-09-22 16:30
Stadium: Scott Stadium Round: 1
Home Manager: Bronco Mendenhall Away Manager: Bobby Petrino
Head to Head
| NCAAF | 2017/11/11 20:30 | Virginia v Louisville | W | 21-38 |
| NCAAF | 2016/10/29 16:00 | Louisville v Virginia | W | 32-25 |
| NCAAF | 2015/11/14 17:30 | Louisville v Virginia | W | 38-31 |
| NCAAF | 2014/09/13 16:30 | Virginia v Louisville | L | 23-21 |
Home History
| NCAAF | 2018/09/15 23:30 | Western Kentucky v Louisville | W | 17-20 |
| NCAAF | 2018/09/08 23:00 | Indiana State v Louisville | W | 7-31 |
| NCAAF | 2018/09/02 00:00 | Louisville v Alabama | L | 14-51 |
| NCAAF | 2017/12/30 17:00 | Louisville v Mississippi State | L | 27-31 |
| NCAAF | 2017/11/25 17:00 | Louisville v Kentucky | W | 44-17 |
| NCAAF | 2017/11/18 20:30 | Syracuse v Louisville | W | 10-56 |
| NCAAF | 2017/11/11 20:30 | Virginia v Louisville | W | 21-38 |
| NCAAF | 2017/10/28 16:20 | Louisville v Wake Forest | L | 32-42 |
Away History
| NCAAF | 2018/09/15 20:30 | Ohio v Virginia | W | 31-45 |
| NCAAF | 2018/09/08 23:30 | Virginia v Indiana | L | 16-20 |
| NCAAF | 2018/09/01 22:00 | Richmond v Virginia | W | 13-42 |
| NCAAF | 2017/12/28 18:30 | Virginia v Navy | L | 7-49 |
| NCAAF | 2017/11/25 01:00 | Virginia Tech v Virginia | L | 10-0 |
| NCAAF | 2017/11/18 17:00 | Virginia v Miami Florida | L | 28-44 |
| NCAAF | 2017/11/11 20:30 | Virginia v Louisville | L | 21-38 |
| NCAAF | 2017/11/04 19:00 | Georgia Tech v Virginia | W | 36-40 |