[2] Roger Federer 6-3,6-2 Nick Kyrgios [27] 2018-09-22 20:05
Stadium: United Center Round: 44 Ground: Hardcourt indoor
Head to Head
| US Open | 2018/09/01 18:05 | Nick Kyrgios v Roger Federer | 4-6,1-6,5-7 |
| ATP Stuttgart | 2018/06/16 14:00 | Roger Federer v Nick Kyrgios | 6-7,6-2,7-6 |
| Laver Cup | 2017/09/24 15:45 | Roger Federer v Nick Kyrgios | 4-6,7-6,11-9 |
| ATP Miami | 2017/03/31 23:00 | Nick Kyrgios v Roger Federer | 6-7,7-6,6-7 |
| ATP Madrid | 2015/05/06 16:45 | Roger Federer v Nick Kyrgios | 7-6,6-7,6-7 |
Home History
| US Open | 2018/09/04 01:00 | John Millman v Roger Federer | 3-6,7-5,7-6,7-6 |
| US Open | 2018/09/01 18:05 | Nick Kyrgios v Roger Federer | 4-6,1-6,5-7 |
| US Open | 2018/08/30 18:45 | Benoit Paire v Roger Federer | 5-7,4-6,4-6 |
| US Open | 2018/08/28 23:00 | Yoshihito Nishioka v Roger Federer | 2-6,2-6,4-6 |
| ATP Cincinnati | 2018/08/19 20:25 | Novak Djokovic v Roger Federer | 6-4,6-4 |
| ATP Cincinnati | 2018/08/18 01:05 | Stan Wawrinka v Roger Federer | 7-6,6-7,2-6 |
| ATP Cincinnati | 2018/08/17 18:00 | Leonardo Mayer v Roger Federer | 1-6,6-7 |
| ATP Cincinnati | 2018/08/14 23:00 | Peter Gojowczyk v Roger Federer | 4-6,4-6 |
Away History
| US Open | 2018/09/01 18:05 | Nick Kyrgios v Roger Federer | 4-6,1-6,5-7 |
| US Open | 2018/08/30 16:10 | Nick Kyrgios v Pierre-Hugues Herbert | 4-6,7-6,6-3,6-0 |
| US Open | 2018/08/28 23:00 | Nick Kyrgios v Radu Albot | 7-5,2-6,6-4,6-2 |
| ATP Cincinnati | 2018/08/17 15:00 | Nick Kyrgios v Juan Martin Del Potro | 6-7,7-6,2-6 |
| ATP Cincinnati | 2018/08/15 23:55 | Nick Kyrgios v Borna Coric | 7-6,0-6,6-3 |
| ATP Cincinnati | 2018/08/14 17:10 | Nick Kyrgios v Denis Kudla | 6-7,7-5,7-6 |
| ATP Toronto | 2018/08/07 15:00 | Stan Wawrinka v Nick Kyrgios | 1-6,7-5,7-5 |
| ATP Atlanta | 2018/07/26 23:00 | Noah Rubin v Nick Kyrgios | 5-7,2-6 |