Northwestern 29-19 Michigan State 2018-10-06 16:00
Stadium: Spartan Stadium Round: 1
Home Manager: Mark Dantonio Away Manager: Pat Fitzgerald
Head to Head
| NCAAF | 2017/10/28 19:30 | Michigan State v Northwestern | W | 31-39 |
| NCAAF | 2016/10/15 19:30 | Northwestern v Michigan State | W | 54-40 |
| NCAAF | 2012/11/17 12:00 | Michigan State v Northwestern | W | 20-23 |
| NCAAF | 2011/11/26 12:00 | Northwestern v Michigan State | L | 17-31 |
| NCAAF | 2010/10/23 12:00 | Northwestern v Michigan State | L | 27-35 |
| NCAAF | 2009/10/17 12:00 | Michigan State v Northwestern | L | 24-14 |
| NCAAF | 2008/10/11 12:00 | Northwestern v Michigan State | L | 20-37 |
| NCAAF | 2007/10/06 12:00 | Michigan State v Northwestern | W | 41-48 |
Home History
| NCAAF | 2018/09/29 20:30 | Michigan v Northwestern | L | 20-17 |
| NCAAF | 2018/09/15 23:30 | Akron v Northwestern | L | 39-34 |
| NCAAF | 2018/09/08 16:00 | Duke v Northwestern | L | 21-7 |
| NCAAF | 2018/08/31 00:00 | Northwestern v Purdue | W | 31-27 |
| NCAAF | 2017/12/29 21:30 | Kentucky v Northwestern | W | 23-24 |
| NCAAF | 2017/11/25 21:00 | Northwestern v Illinois | W | 42-7 |
| NCAAF | 2017/11/18 17:00 | Minnesota v Northwestern | W | 0-39 |
| NCAAF | 2017/11/12 00:00 | Purdue v Northwestern | W | 13-23 |
Away History
| NCAAF | 2018/09/29 16:00 | Central Michigan v Michigan State | W | 20-31 |
| NCAAF | 2018/09/22 23:30 | Michigan State v Indiana | W | 35-21 |
| NCAAF | 2018/09/09 02:45 | Michigan State v Arizona State | L | 13-16 |
| NCAAF | 2018/08/31 23:00 | Utah State v Michigan State | W | 31-38 |
| NCAAF | 2017/12/29 02:00 | Michigan State v Washington State | W | 42-17 |
| NCAAF | 2017/11/25 21:00 | Michigan State v Rutgers | W | 40-7 |
| NCAAF | 2017/11/18 21:00 | Maryland v Michigan State | W | 7-17 |
| NCAAF | 2017/11/11 17:00 | Michigan State v Ohio State | L | 3-48 |