Head to Head
| Ghana Premier League | 2025/01/05 15:00 | Medeama SC v Asante Kotoko | D | 1-1 |
| World Club Friendlies | 2024/08/16 17:00 | Medeama SC v Asante Kotoko | L | 2-1 |
| Ghana Premier League | 2024/04/27 15:00 | Medeama SC v Asante Kotoko | D | 1-1 |
| Ghana Premier League | 2023/11/19 15:00 | Asante Kotoko v Medeama SC | W | 1-0 |
| Ghana Premier League | 2023/03/26 18:00 | Asante Kotoko v Medeama SC | L | 0-2 |
| Ghana Premier League | 2022/11/12 15:00 | Medeama SC v Asante Kotoko | W | 0-1 |
| Ghana Premier League | 2022/05/29 15:00 | Medeama SC v Asante Kotoko | W | 0-2 |
| Ghana Premier League | 2022/01/23 15:00 | Asante Kotoko v Medeama SC | W | 1-0 |
Home History
| Ghana Premier League | 2025/02/02 15:00 | Nsoatreman FC v Asante Kotoko | L | 1-0 |
| Ghana Premier League | 2025/01/26 15:00 | Asante Kotoko v Karela United FC | W | 1-0 |
| Ghana Premier League | 2025/01/19 15:00 | Asante Kotoko v Vision FC | W | 4-1 |
| Ghana FA Cup | 2025/01/12 15:00 | Acceller8Z FC v Asante Kotoko | W | 0-2 |
| Ghana Premier League | 2025/01/05 15:00 | Medeama SC v Asante Kotoko | D | 1-1 |
| Ghana Premier League | 2024/12/27 18:00 | Asante Kotoko v Bibiani Gold Stars | W | 2-0 |
| Ghana Premier League | 2024/12/21 15:00 | Dreams v Asante Kotoko | W | 1-2 |
| Ghana Premier League | 2024/12/15 15:00 | Asante Kotoko v Hearts of Oak | W | 1-0 |
Away History
| Ghana Premier League | 2025/02/02 15:00 | Medeama SC v Legon Cities FC | W | 1-0 |
| Ghana Premier League | 2025/01/25 15:00 | Accra Lions FC v Medeama SC | L | 1-0 |
| Ghana Premier League | 2025/01/19 15:00 | Berekum Chelsea v Medeama SC | L | 2-1 |
| Ghana Premier League | 2025/01/08 15:00 | Nsoatreman FC v Medeama SC | D | 1-1 |
| Ghana Premier League | 2025/01/05 15:00 | Medeama SC v Asante Kotoko | D | 1-1 |
| Ghana Premier League | 2025/01/01 15:00 | Medeama SC v Karela United FC | W | 1-0 |
| Ghana Premier League | 2024/12/14 15:00 | Vision FC v Medeama SC | L | 3-2 |
| Ghana Premier League | 2024/11/24 15:00 | Young Apostles v Medeama SC | W | 0-2 |