Houston 42-20 East Carolina 2018-10-13 23:00
Stadium: Bagwell Field at Dowdy-Ficklen Stadium Round: 1
Home Manager: Scottie Montgomery Away Manager: Major Applewhite
Head to Head
| NCAAF | 2017/11/04 16:00 | East Carolina v Houston | W | 27-52 |
| NCAAF | 2012/11/03 12:00 | East Carolina v Houston | L | 48-28 |
| NCAAF | 2011/10/08 12:00 | Houston v East Carolina | W | 56-3 |
| NCAAF | 2009/12/05 12:00 | East Carolina v Houston | L | 38-32 |
| NCAAF | 2008/09/27 12:00 | East Carolina v Houston | W | 24-41 |
| NCAAF | 2007/09/29 12:00 | Houston v East Carolina | L | 35-37 |
| NCAAF | 2004/11/06 12:00 | Houston v East Carolina | W | 34-24 |
| NCAAF | 2003/09/30 12:00 | East Carolina v Houston | W | 13-27 |
Home History
| NCAAF | 2018/10/05 00:00 | Tulsa v Houston | W | 26-41 |
| NCAAF | 2018/09/23 00:00 | Texas Southern Tigers v Houston | W | 14-70 |
| NCAAF | 2018/09/15 20:15 | Houston v Texas Tech | L | 49-63 |
| NCAAF | 2018/09/08 16:00 | Arizona v Houston | W | 18-45 |
| NCAAF | 2018/09/01 16:00 | Houston v Rice | W | 45-27 |
| NCAAF | 2017/12/25 01:30 | Houston v Fresno State | L | 27-33 |
| NCAAF | 2017/11/24 17:00 | Navy v Houston | W | 14-24 |
| NCAAF | 2017/11/18 21:00 | Houston v Tulane | L | 17-20 |
Away History
| NCAAF | 2018/10/06 16:00 | East Carolina v Temple | L | 6-49 |
| NCAAF | 2018/09/29 19:30 | Old Dominion v East Carolina | W | 35-37 |
| NCAAF | 2018/09/23 00:00 | East Carolina v South Florida | L | 13-20 |
| NCAAF | 2018/09/08 19:30 | North Carolina v East Carolina | W | 19-41 |
| NCAAF | 2018/09/02 19:30 | North Carolina A&T v East Carolina | L | 28-23 |
| NCAAF | 2017/11/25 17:00 | East Carolina v Memphis | L | 13-70 |
| NCAAF | 2017/11/18 17:00 | Cincinnati v East Carolina | W | 20-48 |
| NCAAF | 2017/11/12 00:00 | East Carolina v Tulane | L | 24-31 |