Stadium: Panther Stadium at Blackshear Field Round: 1
Home Manager: Eric Dooley Away Manager: Dawson Odums
| NCAAF | 2018/09/29 23:00 | Alcorn State v Southern | L | 20-3 |
| NCAAF | 2018/09/22 21:00 | Alabama v Southern | W | 27-29 |
| NCAAF | 2018/09/08 23:00 | Southern v Louisiana Tech | L | 17-54 |
| NCAAF | 2018/09/01 16:00 | Southern v TCU | L | 7-55 |
| NCAAF | 2017/11/25 22:00 | Grambling State v Southern | L | 30-21 |
| NCAAF | 2017/11/11 23:00 | Texas Southern Tigers v Southern | W | 7-33 |
| NCAAF | 2017/11/04 21:00 | Southern v Prairie View | W | 37-31 |
| NCAAF | 2017/10/28 21:00 | Arkansas Pine Bluff v Southern | W | 40-47 |
| NCAAF | 2018/09/29 21:00 | Prairie View v Grambling State | W | 22-16 |
| NCAAF | 2018/09/22 23:00 | Prairie View v Arkansas Pine Bluff | W | 62-13 |
| NCAAF | 2018/09/16 02:00 | Prairie View v UNLV | L | 17-46 |
| NCAAF | 2018/09/08 23:00 | Prairie View v Sam Houston State | L | 32-41 |
| NCAAF | 2018/09/02 16:00 | Prairie View v North Carolina Central | W | 40-24 |
| NCAAF | 2018/08/25 23:00 | Prairie View v Rice | L | 28-31 |
| NCAAF | 2017/11/26 00:00 | Texas Southern Tigers v Prairie View | W | 16-30 |
| NCAAF | 2017/11/17 00:00 | Incarnate Word v Prairie View | W | 28-42 |