Louisville 16-77 Clemson 2018-11-03 16:00
Stadium: Memorial Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Bobby Petrino
Head to Head
| NCAAF | 2017/09/17 00:00 | Clemson v Louisville | L | 47-21 |
| NCAAF | 2016/10/02 00:00 | Louisville v Clemson | L | 36-42 |
| NCAAF | 2015/09/17 23:30 | Louisville v Clemson | L | 17-20 |
| NCAAF | 2014/10/11 19:30 | Clemson v Louisville | L | 23-17 |
Home History
| NCAAF | 2018/10/27 16:00 | Wake Forest v Louisville | L | 56-35 |
| NCAAF | 2018/10/13 16:30 | Louisville v Boston College | L | 20-38 |
| NCAAF | 2018/10/05 23:00 | Georgia Tech v Louisville | L | 66-31 |
| NCAAF | 2018/09/29 19:30 | Florida State v Louisville | L | 28-24 |
| NCAAF | 2018/09/22 16:30 | Louisville v Virginia | L | 3-27 |
| NCAAF | 2018/09/15 23:30 | Western Kentucky v Louisville | W | 17-20 |
| NCAAF | 2018/09/08 23:00 | Indiana State v Louisville | W | 7-31 |
| NCAAF | 2018/09/02 00:00 | Louisville v Alabama | L | 14-51 |
Away History
| NCAAF | 2018/10/27 16:00 | Clemson v Florida State | W | 59-10 |
| NCAAF | 2018/10/27 16:00 | Florida State v Clemson | W | 10-59 |
| NCAAF | 2018/10/20 19:30 | NC State v Clemson | W | 7-41 |
| NCAAF | 2018/10/06 19:30 | Clemson v Wake Forest | W | 63-3 |
| NCAAF | 2018/09/29 16:00 | Syracuse v Clemson | W | 23-27 |
| NCAAF | 2018/09/22 19:30 | Clemson v Georgia Tech | W | 49-21 |
| NCAAF | 2018/09/15 16:00 | Georgia Southern v Clemson | W | 7-38 |
| NCAAF | 2018/09/08 23:00 | Clemson v Texas A&M | W | 28-26 |