Wake Forest 56-35 Louisville 2018-10-27 16:00
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Bobby Petrino Away Manager: Dave Clawson
Head to Head
| NCAAF | 2017/10/28 16:20 | Louisville v Wake Forest | W | 32-42 |
| NCAAF | 2016/11/13 00:00 | Wake Forest v Louisville | L | 12-44 |
| NCAAF | 2015/10/30 23:00 | Wake Forest v Louisville | L | 19-20 |
| NCAAF | 2014/09/27 19:30 | Louisville v Wake Forest | L | 20-10 |
| NCAAF Bowl Games | 2007/01/02 12:00 | Louisville v Wake Forest | L | 24-13 |
Home History
| NCAAF | 2018/10/20 19:30 | Wake Forest v Florida State | L | 17-38 |
| NCAAF | 2018/10/06 19:30 | Clemson v Wake Forest | L | 63-3 |
| NCAAF | 2018/09/29 19:30 | Rice v Wake Forest | W | 24-56 |
| NCAAF | 2018/09/22 16:00 | Notre Dame v Wake Forest | L | 56-27 |
| NCAAF | 2018/09/13 21:30 | Boston College v Wake Forest | L | 41-34 |
| NCAAF | 2018/09/08 16:00 | Towson v Wake Forest | W | 20-51 |
| NCAAF | 2018/08/31 00:00 | Wake Forest v Tulane | W | 23-17 |
| NCAAF | 2017/12/29 18:00 | Texas A&M v Wake Forest | W | 52-55 |
Away History
| NCAAF | 2018/10/13 16:30 | Louisville v Boston College | L | 20-38 |
| NCAAF | 2018/10/05 23:00 | Georgia Tech v Louisville | L | 66-31 |
| NCAAF | 2018/09/29 19:30 | Florida State v Louisville | L | 28-24 |
| NCAAF | 2018/09/22 16:30 | Louisville v Virginia | L | 3-27 |
| NCAAF | 2018/09/15 23:30 | Western Kentucky v Louisville | W | 17-20 |
| NCAAF | 2018/09/08 23:00 | Indiana State v Louisville | W | 7-31 |
| NCAAF | 2018/09/02 00:00 | Louisville v Alabama | L | 14-51 |
| NCAAF | 2017/12/30 17:00 | Louisville v Mississippi State | L | 27-31 |