South Florida 36-57 Houston 2018-10-27 19:30
Stadium: Space City Financial Stadium Round: 1
Home Manager: Major Applewhite Away Manager: Charlie Strong
Head to Head
| NCAAF | 2017/10/28 19:45 | Houston v South Florida | L | 28-24 |
| NCAAF | 2014/11/01 20:00 | South Florida v Houston | L | 3-27 |
| NCAAF | 2002/11/23 12:00 | Houston v South Florida | W | 14-32 |
| NCAAF | 2001/11/03 12:00 | South Florida v Houston | W | 45-6 |
Home History
| NCAAF | 2018/10/20 23:00 | Connecticut v South Florida | W | 30-38 |
| NCAAF | 2018/10/12 23:00 | South Florida v Tulsa | W | 25-24 |
| NCAAF | 2018/10/06 19:30 | South Florida v Massachusetts | W | 58-42 |
| NCAAF | 2018/09/23 00:00 | East Carolina v South Florida | W | 13-20 |
| NCAAF | 2018/09/15 19:30 | South Florida v Illinois | W | 25-19 |
| NCAAF | 2018/09/08 16:00 | Georgia Tech v South Florida | W | 38-49 |
| NCAAF | 2018/09/01 22:00 | Elon v South Florida | W | 14-34 |
| NCAAF | 2017/12/23 17:00 | Texas Tech v South Florida | W | 34-38 |
Away History
| NCAAF | 2018/10/20 19:30 | Houston v Navy | W | 49-36 |
| NCAAF | 2018/10/13 23:00 | Houston v East Carolina | W | 42-20 |
| NCAAF | 2018/10/05 00:00 | Tulsa v Houston | W | 26-41 |
| NCAAF | 2018/09/23 00:00 | Texas Southern Tigers v Houston | W | 14-70 |
| NCAAF | 2018/09/15 20:15 | Houston v Texas Tech | L | 49-63 |
| NCAAF | 2018/09/08 16:00 | Arizona v Houston | W | 18-45 |
| NCAAF | 2018/09/01 16:00 | Houston v Rice | W | 45-27 |
| NCAAF | 2017/12/25 01:30 | Houston v Fresno State | L | 27-33 |