| NCAAF | 2018/11/03 16:00 | Thomas More Saints v Lake Erie | L | 44-0 |
| NCAAF | 2018/10/27 16:00 | Lake Erie v Tiffin Dragons | L | 28-40 |
| NCAAF | 2018/10/20 18:00 | Kentucky Wesleyan v Lake Erie | L | 46-6 |
| NCAAF | 2018/10/13 23:00 | Lake Erie v Walsh U. Cavaliers | L | 0-29 |
| NCAAF | 2018/10/06 17:30 | Alderson Broaddus Battlers v Lake Erie | L | 55-27 |
| NCAAF | 2018/09/29 16:00 | Lake Erie v Findlay Oilers | L | 7-70 |
| NCAAF | 2018/09/22 20:00 | Hillsdale Chargers v Lake Erie | L | 41-7 |
| NCAAF | 2018/09/13 23:00 | Urbana Blue Knights v Lake Erie | L | 27-19 |
| NCAAF | 2018/11/03 16:00 | Ohio Dominican Panthers v Kentucky Wesleyan | W | 65-7 |
| NCAAF | 2018/10/27 17:05 | East Stroudsburg Warriors v Ohio Dominican Panthers | W | 35-48 |
| NCAAF | 2018/10/20 20:00 | Tiffin Dragons v Ohio Dominican Panthers | L | 24-23 |
| NCAAF | 2018/10/13 17:00 | Ohio Dominican Panthers v Malone University Pioneers | W | 57-17 |
| NCAAF | 2018/10/06 23:00 | Walsh U. Cavaliers v Ohio Dominican Panthers | W | 10-20 |
| NCAAF | 2018/09/29 16:00 | Ohio Dominican Panthers v Alderson Broaddus Battlers | W | 66-27 |
| NCAAF | 2018/09/22 23:05 | Findlay Oilers v Ohio Dominican Panthers | W | 21-34 |
| NCAAF | 2018/09/15 23:00 | Ohio Dominican Panthers v Hillsdale Chargers | L | 18-34 |