[18] Karen Khachanov 6-4,6-7,7-6 John Isner [9] 2018-11-01 12:00
Stadium: Court 1 Round: 26 Ground: Hardcourt indoor
Head to Head
| ATP Toronto | 2018/08/09 22:40 | Karen Khachanov v John Isner | 7-6,7-6 |
| French Open | 2017/06/03 14:15 | John Isner v Karen Khachanov | 6-7,3-6,7-6,6-7 |
Home History
| ATP Paris | 2018/10/29 10:00 | Karen Khachanov v Filip Krajinovic | 7-5,6-2 |
| ATP Vienna | 2018/10/25 11:00 | Karen Khachanov v Kei Nishikori | 2-6,2-6 |
| ATP Vienna | 2018/10/24 13:10 | Karen Khachanov v Dennis Novak | 6-3,7-5 |
| ATP Moscow | 2018/10/21 13:00 | Adrian Mannarino v Karen Khachanov | 2-6,2-6 |
| ATP Moscow | 2018/10/20 14:50 | Karen Khachanov v Daniil Medvedev | 6-1,6-7,6-3 |
| ATP Moscow | 2018/10/19 17:45 | Mirza Basic v Karen Khachanov | 2-6,6-7 |
| ATP Moscow | 2018/10/17 12:40 | Lukas Rosol v Karen Khachanov | 4-6,5-7 |
| ATP Shanghai | 2018/10/10 06:40 | Karen Khachanov v Stefanos Tsitsipas | 4-6,6-7 |
Away History
| ATP Paris | 2018/10/31 10:00 | Mikhail Kukushkin v John Isner | 3-6,7-6,6-7 |
| ATP Vienna | 2018/10/25 17:00 | Gael Monfils v John Isner | 6-4,6-4 |
| ATP Vienna | 2018/10/23 13:30 | Cameron Norrie v John Isner | 7-6,4-6,6-7 |
| ATP Stockholm | 2018/10/20 13:00 | John Isner v Ernests Gulbis | 6-1,3-6,3-6 |
| ATP Stockholm | 2018/10/19 19:10 | John Isner v Tennys Sandgren | 7-6,6-7,7-6 |
| ATP Stockholm | 2018/10/18 17:30 | John Isner v Bradley Klahn | 7-6,6-7,7-6 |
| Laver Cup | 2018/09/23 19:00 | Roger Federer v John Isner | 6-7,7-6,10-7 |
| Laver Cup | 2018/09/23 18:30 | Roger Federer v John Isner | 6-7,7-6,1-0 |