[7] Guarani Asuncion 1-3 River Plate Asuncion [3] 2019-07-12 23:30
Stadium: Estadio Defensores del Chaco Round: 1
Referee: Ulises Mereles Home Manager: Gustavo Costas Away Manager: Daniel Farrar
Head to Head
| Paraguay Division Profesional | 2019/05/06 23:30 | River Plate Asuncion v Guarani Asuncion | W | 0-1 |
| Paraguay Division Profesional | 2019/03/04 21:45 | Guarani Asuncion v River Plate Asuncion | W | 2-1 |
| Paraguay Division Profesional | 2016/10/16 23:10 | River Plate Asuncion v Guarani Asuncion | W | 0-2 |
| Paraguay Division Profesional | 2016/07/20 21:00 | Guarani Asuncion v River Plate Asuncion | W | 2-0 |
| Paraguay Division Profesional | 2016/04/30 22:00 | Guarani Asuncion v River Plate Asuncion | W | 4-2 |
| Paraguay Division Profesional | 2016/02/27 21:30 | River Plate Asuncion v Guarani Asuncion | D | 1-1 |