Stadium: James H. Hilton Coliseum Round: 1
Home Manager: Steve Prohm Away Manager: Lindsey Hunter
| NCAAB | 2016/12/21 00:00 | Iowa State v Mississippi Valley State | L | 88-60 |
| NCAAB | 2015/01/01 00:00 | Iowa State v Mississippi Valley State | L | 83-33 |
| NCAAB | 2011/12/31 12:00 | Iowa State v Mississippi Valley State | L | 67-65 |
| NCAAB | 2009/11/22 12:00 | Iowa State v Mississippi Valley State | L | 96-55 |
| NCAAB | 2008/11/29 12:00 | Iowa State v Mississippi Valley State | L | 77-59 |