[3] Santos Laguna 1-2 Leon [16] 2021-03-22 01:06
Stadium: Estadio TSM Corona Round: 12
Referee: Oscar Mejia Garcia Home Manager: Guillermo Almada Away Manager: Marcos Ignacio Ambriz
Head to Head
| Mexico Liga MX | 2020/11/03 03:00 | Leon v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2020/01/20 00:45 | Santos Laguna v Leon | W | 3-2 |
| Mexico Liga MX | 2019/08/29 00:00 | Leon v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2019/03/03 01:00 | Leon v Santos Laguna | L | 3-0 |
| Mexico Liga MX | 2018/09/16 21:00 | Santos Laguna v Leon | W | 3-0 |
| Mexico Liga MX | 2018/02/15 01:00 | Santos Laguna v Leon | W | 5-1 |
| Mexico Liga MX | 2017/08/27 00:06 | Leon v Santos Laguna | W | 1-2 |
| Mexico Liga MX | 2017/02/19 01:06 | Leon v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2016/08/28 23:00 | Santos Laguna v Leon | W | 1-0 |
| Mexico Liga MX | 2016/01/10 02:06 | Leon v Santos Laguna | L | 2-0 |
| Mexico Liga MX | 2015/07/26 02:00 | Santos Laguna v Leon | L | 1-3 |
| Mexico Liga MX | 2015/03/01 02:06 | Leon v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2014/09/13 02:30 | Santos Laguna v Leon | W | 2-0 |