[1] Cruz Azul 3-2 Atletico San Luis [16] 2021-04-24 22:00
Stadium: Estadio Azteca Round: 16
Referee: Luis Enrique Santander Aguirre Home Manager: Luis Armando Gonzalez Bejarano Away Manager: Leonel Rocco
Head to Head
| Mexico Liga MX | 2020/08/24 00:35 | Atletico San Luis v Cruz Azul | W | 1-3 |
| Mexico Liga MX | 2020/01/18 01:00 | Atletico San Luis v Cruz Azul | L | 2-1 |
| Mexico Liga MX | 2019/11/24 01:00 | Cruz Azul v Atletico San Luis | W | 3-1 |