[8] River Plate Asuncion 0-1 Guairena FC [4] 2021-03-05 21:15
Stadium: Estadio River Plate Round: 6
Referee: Alipio Colman Home Manager: Ariel Galeano Away Manager: Troadio Daniel Duarte
Head to Head
| Paraguay Division Profesional | 2020/11/10 23:45 | River Plate Asuncion v Guairena FC | L | 1-2 |
| Paraguay Division Profesional | 2020/08/12 20:00 | River Plate Asuncion v Guairena FC | W | 2-1 |
| Paraguay Division Profesional | 2020/01/25 21:00 | Guairena FC v River Plate Asuncion | L | 2-0 |
| Paraguay Division Intermedia | 2018/07/29 13:30 | Guairena FC v River Plate Asuncion | L | 3-0 |
| Paraguay Division Intermedia | 2018/04/21 13:30 | River Plate Asuncion v Guairena FC | W | 3-1 |
| Paraguay Division Intermedia | 2017/06/24 14:00 | River Plate Asuncion v Guairena FC | D | 1-1 |
| Paraguay Division Intermedia | 2017/03/19 19:30 | Guairena FC v River Plate Asuncion | L | 1-0 |