[6] Guarani Asuncion 0-3 Guairena FC [5] 2021-03-14 20:45
Stadium: Estadio Rogelio Silvino Livieres Round: 8
Referee: Mario Alberto Diaz De Vivar Home Manager: Gustavo Costas Away Manager: Troadio Daniel Duarte
Head to Head
| Paraguay Division Profesional | 2020/12/28 00:00 | Guairena FC v Guarani Asuncion | W | 0-1 |
| Paraguay Division Profesional | 2020/12/19 22:30 | Guarani Asuncion v Guairena FC | W | 1-0 |
| Paraguay Division Profesional | 2020/09/20 21:00 | Guarani Asuncion v Guairena FC | D | 0-0 |
| Paraguay Division Profesional | 2020/07/23 22:00 | Guairena FC v Guarani Asuncion | D | 1-1 |