[17] Santiago Wanderers 2-2 La Serena [9] 2021-08-21 15:30
Stadium: Estadio Elias Figueroa Brander Round: 17
Referee: Rodrigo Carvajal Home Manager: Emiliano Astorga Away Manager: Miguel Ponce
Head to Head
| Chile Primera Division | 2021/01/18 20:00 | Santiago Wanderers v La Serena | D | 0-0 |
| Chile Primera Division | 2020/02/23 15:00 | La Serena v Santiago Wanderers | L | 3-0 |
| Chile Primera B | 2019/09/14 23:00 | Santiago Wanderers v La Serena | W | 4-1 |
| Chile Primera B | 2019/05/11 19:30 | La Serena v Santiago Wanderers | D | 0-0 |
| Chile Primera B | 2018/09/24 21:00 | La Serena v Santiago Wanderers | D | 1-1 |
| Chile Primera B | 2018/04/21 18:00 | Santiago Wanderers v La Serena | D | 1-1 |
| Chile Cup | 2016/07/17 19:00 | Santiago Wanderers v La Serena | W | 2-1 |
| Chile Cup | 2016/07/09 00:00 | La Serena v Santiago Wanderers | L | 3-1 |