[5] Guairena FC 0-0 Guarani Asuncion [6] 2021-05-21 23:00
Stadium: Estadio Parque del Guaira Round: 17
Referee: Derlis Lopez Home Manager: Troadio Daniel Duarte Away Manager: Gustavo Costas
Head to Head
| Paraguay Division Profesional | 2021/03/14 20:45 | Guarani Asuncion v Guairena FC | W | 0-3 |
| Paraguay Division Profesional | 2020/12/28 00:00 | Guairena FC v Guarani Asuncion | L | 0-1 |
| Paraguay Division Profesional | 2020/12/19 22:30 | Guarani Asuncion v Guairena FC | L | 1-0 |
| Paraguay Division Profesional | 2020/09/20 21:00 | Guarani Asuncion v Guairena FC | D | 0-0 |
| Paraguay Division Profesional | 2020/07/23 22:00 | Guairena FC v Guarani Asuncion | D | 1-1 |