[5] Santos Laguna 0-1 Cruz Azul [1] 2021-05-28 02:00
Stadium: Estadio TSM Corona Round: 1
Referee: Fernando Guerrero Ramirez Home Manager: Guillermo Almada Away Manager: Luis Armando Gonzalez Bejarano
Head to Head
| Mexico Liga MX | 2021/01/11 01:06 | Santos Laguna v Cruz Azul | W | 1-0 |
| Mexico Liga MX | 2020/07/26 02:00 | Cruz Azul v Santos Laguna | L | 2-0 |
| Mexico Liga MX | 2020/01/25 23:00 | Cruz Azul v Santos Laguna | L | 3-0 |
| Mexico Liga MX | 2019/11/11 00:45 | Santos Laguna v Cruz Azul | W | 3-1 |
| Mexico Liga MX | 2019/02/16 23:00 | Cruz Azul v Santos Laguna | W | 1-2 |
| Mexico Liga MX | 2018/08/26 23:00 | Santos Laguna v Cruz Azul | D | 1-1 |
| Mexico Liga MX | 2018/02/26 00:00 | Santos Laguna v Cruz Azul | W | 2-0 |
| Mexico Liga MX | 2017/09/16 22:00 | Cruz Azul v Santos Laguna | L | 2-1 |
| Mexico Cup | 2017/03/15 01:00 | Santos Laguna v Cruz Azul | L | 1-3 |
| Mexico Liga MX | 2017/02/13 00:00 | Santos Laguna v Cruz Azul | D | 2-2 |
| Mexico Liga MX | 2016/08/20 22:00 | Cruz Azul v Santos Laguna | L | 3-1 |
| Mexico Liga MX | 2016/04/16 22:00 | Cruz Azul v Santos Laguna | W | 0-1 |
| Mexico Liga MX | 2015/10/24 02:30 | Santos Laguna v Cruz Azul | L | 1-2 |
| Mexico Liga MX | 2015/01/17 23:00 | Cruz Azul v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2014/07/26 02:30 | Santos Laguna v Cruz Azul | D | 1-1 |