[9] Libertad Asuncion 0-0 Guairena FC [8] 2021-07-18 23:30
Stadium: Estadio Dr. Nicolás Léoz Round: 1
Referee: Jose Mendez Home Manager: Daniel Garnero Away Manager: Troadio Daniel Duarte
Head to Head
| Paraguay Division Profesional | 2021/04/12 00:30 | Libertad Asuncion v Guairena FC | W | 2-1 |
| Paraguay Division Profesional | 2021/02/24 22:00 | Guairena FC v Libertad Asuncion | L | 1-0 |
| Paraguay Division Profesional | 2020/10/17 23:15 | Guairena FC v Libertad Asuncion | W | 0-3 |
| Paraguay Division Profesional | 2020/09/05 21:30 | Libertad Asuncion v Guairena FC | W | 5-2 |
| Paraguay Division Profesional | 2020/02/28 23:00 | Guairena FC v Libertad Asuncion | L | 3-2 |