[1] Internacional 4-5 Olimpia Asuncion [2] 2021-07-23 00:30
Stadium: Estadio Beira-Rio Round: 4
Referee: Christian Ferreyra Home Manager: Diego Aguirre Away Manager: Sergio Daniel Orteman Rodriguez
Head to Head
| Copa Libertadores Qualification | 2021/07/16 00:30 | Olimpia Asuncion v Internacional | D | 0-0 |
| Copa Libertadores | 2021/05/21 00:00 | Olimpia Asuncion v Internacional | W | 0-1 |
| Copa Libertadores | 2021/05/06 00:00 | Internacional v Olimpia Asuncion | W | 6-1 |