[6] Carlisle 1-1 Leyton Orient [8] 2021-08-21 14:00
Stadium: Brunton Park Round: 4
Referee: Robert Madley Home Manager: Chris Beech Away Manager: Kenneth Francis Jackett
Head to Head
| England League 2 | 2021/05/01 14:00 | Leyton Orient v Carlisle | W | 2-3 |
| England League 2 | 2021/03/23 18:30 | Carlisle v Leyton Orient | L | 0-1 |
| England League 2 | 2019/10/26 14:00 | Leyton Orient v Carlisle | D | 1-1 |
| England League 2 | 2017/02/04 15:00 | Leyton Orient v Carlisle | W | 1-2 |
| England League 2 | 2016/09/10 14:00 | Carlisle v Leyton Orient | D | 2-2 |
| England League 2 | 2016/03/01 19:45 | Carlisle v Leyton Orient | D | 2-2 |
| England League 2 | 2015/09/29 18:45 | Leyton Orient v Carlisle | W | 1-2 |