[17] San Lorenzo 1-2 Colon [13] 2021-10-11 19:45
Stadium: Estadio Pedro Bidegain Round: 15
Referee: Andres Merlos Home Manager: Paolo Montero Away Manager: Eduardo Dominguez
Head to Head
| Argentina Copa de la Liga Profesional | 2021/02/23 00:30 | Colon v San Lorenzo | L | 2-0 |
| Argentina Copa de la Liga Profesional | 2020/12/19 22:20 | San Lorenzo v Colon | D | 2-2 |
| Argentina Superliga | 2019/09/14 20:45 | Colon v San Lorenzo | L | 2-1 |
| Argentina Superliga | 2019/03/23 23:00 | Colon v San Lorenzo | D | 1-1 |
| Argentina Cup | 2018/09/08 00:10 | San Lorenzo v Colon | W | 5-3 |
| Argentina Superliga | 2017/09/30 17:05 | San Lorenzo v Colon | D | 0-0 |
| Argentina Superliga | 2017/06/16 00:30 | Colon v San Lorenzo | L | 2-1 |
| Argentina Liga Profesional | 2016/05/14 18:30 | Colon v San Lorenzo | W | 0-2 |
| Argentina Liga Profesional | 2015/02/14 20:00 | San Lorenzo v Colon | W | 2-0 |