[7] Rayo Vallecano 1-1 Real Betis [3] 2022-01-09 13:00
Stadium: Estadio de Vallecas Round: 20
Referee: Alejandro Muniz Ruiz Home Manager: Andoni Iraola Away Manager: Manuel Pellegrini
Head to Head
| Spain La Liga | 2021/10/24 16:30 | Real Betis v Rayo Vallecano | L | 3-2 |
| Spain Copa del Rey | 2020/01/23 20:00 | Rayo Vallecano v Real Betis | W | 6-4 |
| Spain La Liga | 2019/03/31 12:00 | Rayo Vallecano v Real Betis | D | 1-1 |
| Spain La Liga | 2018/12/09 19:45 | Real Betis v Rayo Vallecano | L | 2-0 |
| Spain La Liga | 2016/02/27 19:30 | Real Betis v Rayo Vallecano | D | 2-2 |
| Spain La Liga | 2015/10/04 10:00 | Rayo Vallecano v Real Betis | L | 0-2 |