[15] Necaxa 0-3 Santos Laguna [8] 2021-07-24 00:00
Stadium: Estadio Victoria Round: 1
Referee: Jorge Antonio Perez Duran Home Manager: Guillermo Alejandro Vazquez Herrera Away Manager: Guillermo Almada
Head to Head
| Mexico Liga MX | 2021/03/08 01:06 | Santos Laguna v Necaxa | L | 3-1 |
| Mexico Liga MX | 2020/08/22 00:30 | Necaxa v Santos Laguna | W | 2-1 |
| Mexico Liga MX | 2020/03/16 00:00 | Santos Laguna v Necaxa | L | 2-1 |
| Mexico Liga MX | 2019/08/18 22:00 | Necaxa v Santos Laguna | W | 3-0 |
| Mexico Liga MX | 2019/03/18 00:06 | Santos Laguna v Necaxa | W | 1-2 |
| Mexico Liga MX | 2018/09/30 02:00 | Necaxa v Santos Laguna | L | 0-1 |
| Mexico Cup | 2018/04/05 02:15 | Necaxa v Santos Laguna | W | 2-1 |
| Mexico Liga MX | 2018/03/04 03:00 | Necaxa v Santos Laguna | L | 1-2 |
| Mexico Cup | 2017/10/26 00:00 | Santos Laguna v Necaxa | L | 2-0 |
| Mexico Liga MX | 2017/10/19 00:00 | Santos Laguna v Necaxa | L | 3-2 |
| Mexico Cup | 2017/03/09 03:00 | Necaxa v Santos Laguna | L | 1-3 |
| Mexico Liga MX | 2017/02/27 00:00 | Santos Laguna v Necaxa | D | 2-2 |
| Mexico Liga MX | 2016/09/11 02:00 | Necaxa v Santos Laguna | W | 2-1 |