[6] Chivas Guadalajara 1-2 Atletico San Luis [6] 2021-07-25 02:00
Stadium: Estadio Akron Round: 1
Referee: Eduardo Galvan Basulto Home Manager: Victor Vucetich Away Manager: Marcelo Mendez
Head to Head
| Mexico Liga MX | 2021/01/22 03:00 | Atletico San Luis v Chivas Guadalajara | L | 3-1 |
| Mexico Liga MX | 2020/08/15 22:00 | Chivas Guadalajara v Atletico San Luis | W | 2-1 |
| Mexico Liga MX | 2020/02/01 01:00 | Atletico San Luis v Chivas Guadalajara | D | 2-2 |
| Mexico Liga MX | 2019/08/11 02:05 | Chivas Guadalajara v Atletico San Luis | W | 3-0 |
| Mexico Cup | 2019/02/28 03:15 | Chivas Guadalajara v Atletico San Luis | W | 2-1 |