[5] Mainz II 3-2 TSG Hoffenheim II [11] 2022-04-02 12:00
Stadium: Stadion am Bruchweg Round: 31
Referee: Arianit Besiri Home Manager: Bartosch Gaul Away Manager: Kai Herdling
Head to Head
| Germany Regionalliga South West | 2021/10/08 15:00 | TSG 1899 Hoffenheim II v Mainz II | W | 0-1 |
| Germany Regionalliga South West | 2021/02/06 13:00 | Mainz II v TSG 1899 Hoffenheim II | L | 0-1 |
| Germany Regionalliga South West | 2020/09/05 12:00 | TSG 1899 Hoffenheim II v Mainz II | W | 1-2 |
| Germany Regionalliga South West | 2020/03/07 14:00 | TSG 1899 Hoffenheim II v Mainz II | W | 1-4 |
| Germany Regionalliga South West | 2019/08/25 12:00 | Mainz II v TSG 1899 Hoffenheim II | L | 0-2 |
| Germany Regionalliga South West | 2019/03/29 15:00 | Mainz II v TSG 1899 Hoffenheim II | D | 2-2 |
| Germany Regionalliga South West | 2018/09/23 12:00 | TSG 1899 Hoffenheim II v Mainz II | L | 3-0 |
| Germany Regionalliga South West | 2018/03/23 18:00 | TSG 1899 Hoffenheim II v Mainz II | L | 2-0 |
| Germany Regionalliga South West | 2017/09/28 16:00 | Mainz II v TSG 1899 Hoffenheim II | L | 0-1 |