[11] Independiente Medellin 3-1 Once Caldas [20] 2021-09-18 01:00
Stadium: Estadio Atanasio Girardot Round: 10
Referee: Lisandro Enrique Castillo Forero Home Manager: Hernan Dario Gomez Jaramillo Away Manager: Eduardo Lara Lozano
Head to Head
| Colombia Cup | 2021/08/04 22:40 | Once Caldas v Independiente Medellin | W | 1-3 |
| Colombia Cup | 2021/07/29 01:05 | Independiente Medellin v Once Caldas | D | 1-1 |
| Colombia Primera A | 2021/04/18 21:30 | Once Caldas v Independiente Medellin | L | 2-0 |
| Colombia Primera A | 2020/11/02 01:10 | Independiente Medellin v Once Caldas | D | 1-1 |
| Colombia Primera A | 2019/09/28 22:00 | Once Caldas v Independiente Medellin | D | 1-1 |
| Colombia Cup | 2019/09/12 01:15 | Independiente Medellin v Once Caldas | W | 1-0 |
| Colombia Cup | 2019/08/29 00:30 | Once Caldas v Independiente Medellin | W | 2-3 |
| Colombia Primera A | 2019/04/05 01:00 | Independiente Medellin v Once Caldas | D | 1-1 |
| Colombia Primera A | 2018/09/02 22:15 | Independiente Medellin v Once Caldas | D | 2-2 |
| Colombia Cup | 2018/08/31 00:30 | Once Caldas v Independiente Medellin | L | 2-1 |
| Colombia Cup | 2018/08/17 00:30 | Independiente Medellin v Once Caldas | L | 0-1 |
| Colombia Primera A | 2018/03/07 23:00 | Once Caldas v Independiente Medellin | L | 3-2 |
| Colombia Primera A | 2017/07/23 00:45 | Once Caldas v Independiente Medellin | D | 0-0 |
| Colombia Primera A | 2017/02/19 01:00 | Independiente Medellin v Once Caldas | W | 1-0 |
| Colombia Primera A | 2016/10/30 00:00 | Once Caldas v Independiente Medellin | W | 1-2 |
| Colombia Primera A | 2016/05/14 22:00 | Independiente Medellin v Once Caldas | W | 2-1 |
| Colombia Cup | 2016/05/05 00:30 | Independiente Medellin v Once Caldas | W | 2-0 |
| Colombia Cup | 2016/02/11 00:30 | Once Caldas v Independiente Medellin | D | 0-0 |
| Colombia Primera A | 2015/07/12 00:45 | Independiente Medellin v Once Caldas | D | 0-0 |
| Colombia Primera A | 2015/01/31 22:30 | Once Caldas v Independiente Medellin | W | 0-2 |
| Colombia Primera A | 2014/08/03 22:30 | Independiente Medellin v Once Caldas | L | 1-3 |