[5] Olimpia Asuncion 0-2 Guairena FC [9] 2021-08-01 23:15
Stadium: Manuel Ferreira Round: 3
Referee: Juan Gabriel Benitez Home Manager: Sergio Daniel Orteman Rodriguez Away Manager: Troadio Daniel Duarte
Head to Head
| Paraguay Division Profesional | 2021/04/16 22:00 | Guairena FC v Olimpia Asuncion | W | 1-2 |
| Paraguay Division Profesional | 2021/02/14 23:45 | Olimpia Asuncion v Guairena FC | D | 0-0 |
| Paraguay Division Profesional | 2020/10/24 23:15 | Guairena FC v Olimpia Asuncion | L | 2-1 |
| Paraguay Division Profesional | 2020/10/04 20:30 | Olimpia Asuncion v Guairena FC | D | 1-1 |
| Paraguay Division Profesional | 2020/08/02 22:30 | Guairena FC v Olimpia Asuncion | W | 0-1 |