[7] Cerro Porteno 2-0 Guairena FC [3] 2021-08-07 23:30
Stadium: General Pablo Rojas Round: 4
Referee: Jose Mendez Home Manager: Francisco Arce Away Manager: Troadio Daniel Duarte
Head to Head
| Paraguay Division Profesional | 2021/04/25 21:45 | Guairena FC v Cerro Porteno | W | 0-1 |
| Paraguay Division Profesional | 2021/02/21 21:30 | Cerro Porteno v Guairena FC | D | 2-2 |
| Paraguay Division Profesional | 2020/11/07 21:15 | Guairena FC v Cerro Porteno | D | 1-1 |
| Paraguay Division Profesional | 2020/08/26 21:00 | Guairena FC v Cerro Porteno | W | 1-2 |
| Paraguay Division Profesional | 2020/02/15 22:15 | Cerro Porteno v Guairena FC | D | 2-2 |