[6] Guimaraes 1-1 Santa Clara [9] 2022-05-01 14:30
Stadium: Dom Afonso Henriques Round: 32
Referee: Hugo Serafim Coelho Magalhaes Silva Home Manager: Pepa Away Manager: Mario Silva
Head to Head
| Portugal Primeira Liga | 2021/12/17 19:00 | Santa Clara v Guimaraes | L | 1-0 |
| Portugal Primeira Liga | 2021/04/17 14:30 | Guimaraes v Santa Clara | W | 1-0 |
| Portugal Primeira Liga | 2020/12/21 20:15 | Santa Clara v Guimaraes | W | 0-4 |
| Portugal Cup | 2020/12/13 14:00 | Guimaraes v Santa Clara | L | 0-1 |
| Portugal Primeira Liga | 2020/07/24 18:00 | Santa Clara v Guimaraes | D | 2-2 |
| Portugal Primeira Liga | 2020/01/18 15:30 | Guimaraes v Santa Clara | W | 1-0 |
| Portugal Primeira Liga | 2019/03/30 20:30 | Santa Clara v Guimaraes | L | 1-0 |
| Portugal Primeira Liga | 2018/11/11 15:00 | Guimaraes v Santa Clara | W | 2-0 |
| Europe Friendlies | 2018/07/22 10:00 | Guimaraes v Santa Clara | W | 3-2 |