[57] Syracuse 3-41 Louisville [85] 2021-11-13 17:00
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Dino Babers
Head to Head
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | L | 0-30 |
| NCAAF | 2019/11/23 21:00 | Syracuse v Louisville | L | 34-56 |
| NCAAF | 2018/11/10 00:00 | Louisville v Syracuse | W | 23-54 |
| NCAAF | 2017/11/18 20:30 | Syracuse v Louisville | L | 10-56 |
| NCAAF | 2016/09/10 00:00 | Louisville v Syracuse | L | 62-28 |
| NCAAF | 2015/11/07 17:30 | Louisville v Syracuse | L | 41-17 |
| NCAAF | 2014/10/03 23:00 | Syracuse v Louisville | L | 6-28 |
| NCAAF | 2012/11/10 12:00 | Syracuse v Louisville | W | 45-26 |
| NCAAF | 2011/10/29 12:00 | Louisville v Syracuse | L | 27-10 |
| NCAAF | 2010/11/06 12:00 | Syracuse v Louisville | L | 20-28 |
| NCAAF | 2009/11/14 12:00 | Louisville v Syracuse | L | 10-9 |
| NCAAF | 2008/11/01 12:00 | Syracuse v Louisville | W | 28-21 |
| NCAAF | 2007/09/22 12:00 | Louisville v Syracuse | W | 35-38 |
| NCAAF | 2006/10/21 12:00 | Syracuse v Louisville | L | 13-28 |
| NCAAF | 2005/11/26 12:00 | Louisville v Syracuse | L | 41-17 |
| NCAAF | 2003/09/13 12:00 | Syracuse v Louisville | L | 20-30 |