[10] Wake Forest 27-48 Clemson [35] 2021-11-20 17:00
Stadium: Memorial Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Dave Clawson
Head to Head
| NCAAF | 2020/09/12 23:30 | Clemson v Wake Forest | L | 37-13 |
| NCAAF | 2019/11/16 20:30 | Wake Forest v Clemson | L | 3-52 |
| NCAAF | 2018/10/06 19:30 | Clemson v Wake Forest | L | 63-3 |
| NCAAF | 2017/10/07 16:00 | Wake Forest v Clemson | L | 14-28 |
| NCAAF | 2016/11/20 00:00 | Clemson v Wake Forest | L | 35-13 |
| NCAAF | 2015/11/21 20:30 | Clemson v Wake Forest | L | 33-13 |
| NCAAF | 2014/11/07 00:30 | Wake Forest v Clemson | L | 20-34 |
| NCAAF | 2012/10/25 12:00 | Wake Forest v Clemson | L | 13-42 |
| NCAAF | 2011/11/12 12:00 | Clemson v Wake Forest | L | 31-28 |
| NCAAF | 2010/11/20 12:00 | Wake Forest v Clemson | L | 10-30 |
| NCAAF | 2009/10/17 12:00 | Clemson v Wake Forest | L | 38-3 |
| NCAAF | 2008/10/09 12:00 | Wake Forest v Clemson | W | 12-7 |
| NCAAF | 2007/11/10 12:00 | Clemson v Wake Forest | L | 44-10 |
| NCAAF | 2006/10/07 12:00 | Wake Forest v Clemson | L | 17-27 |
| NCAAF | 2005/10/01 12:00 | Wake Forest v Clemson | W | 31-27 |
| NCAAF | 2004/09/04 12:00 | Clemson v Wake Forest | L | 37-30 |
| NCAAF | 2003/11/01 12:00 | Wake Forest v Clemson | W | 45-17 |
| NCAAF | 2002/10/19 12:00 | Clemson v Wake Forest | L | 31-23 |
| NCAAF | 2001/10/27 12:00 | Wake Forest v Clemson | L | 14-21 |
| NCAAF | 2000/09/16 12:00 | Clemson v Wake Forest | L | 55-7 |