[84] Middle Tennessee 21-48 Western Kentucky [66] 2021-11-06 19:30
Stadium: Houchens Industries-L.T. Smith Stadium Round: 1
Home Manager: Tyson Helton Away Manager: Rick Stockstill
Head to Head
| NCAAF | 2020/10/03 21:00 | Western Kentucky v Middle Tennessee St. | L | 20-17 |
| NCAAF | 2019/11/30 19:00 | Middle Tennessee St. v Western Kentucky | L | 26-31 |
| NCAAF | 2018/11/03 00:00 | Western Kentucky v Middle Tennessee St. | W | 10-29 |
| NCAAF | 2017/11/18 01:00 | Middle Tennessee St. v Western Kentucky | L | 38-41 |
| NCAAF | 2016/10/15 18:30 | Western Kentucky v Middle Tennessee St. | L | 44-43 |
| NCAAF | 2015/10/10 16:00 | Western Kentucky v Middle Tennessee St. | L | 58-28 |
| NCAAF | 2014/09/13 23:00 | Middle Tennessee St. v Western Kentucky | W | 50-47 |
| NCAAF | 2012/11/01 12:00 | Western Kentucky v Middle Tennessee St. | W | 29-34 |
| NCAAF | 2011/10/06 12:00 | Middle Tennessee St. v Western Kentucky | L | 33-36 |
| NCAAF | 2010/11/20 12:00 | Western Kentucky v Middle Tennessee St. | W | 26-27 |
| NCAAF | 2009/10/24 12:00 | Middle Tennessee St. v Western Kentucky | W | 62-24 |
| NCAAF | 2008/11/15 12:00 | Western Kentucky v Middle Tennessee St. | W | 10-21 |
| NCAAF | 2007/09/20 12:00 | Middle Tennessee St. v Western Kentucky | L | 17-20 |