[15] Leyton Orient 0-1 Colchester [21] 2022-02-05 15:00
Stadium: Matchroom Stadium Round: 30
Referee: Tom Reeves Home Manager: Kenneth Francis Jackett Away Manager: Wayne Brown
Head to Head
| England League 2 | 2021/02/06 15:00 | Leyton Orient v Colchester | D | 0-0 |
| England League 2 | 2020/11/14 15:00 | Colchester v Leyton Orient | L | 2-1 |
| England League 2 | 2019/12/26 13:00 | Leyton Orient v Colchester | L | 1-3 |
| England League 2 | 2019/09/21 14:00 | Colchester v Leyton Orient | L | 2-1 |
| England League 2 | 2017/04/29 14:00 | Leyton Orient v Colchester | L | 1-3 |
| England League 2 | 2016/11/12 15:00 | Colchester v Leyton Orient | W | 0-3 |
| Club Friendly List | 2015/07/25 14:00 | Colchester v Leyton Orient | W | 0-3 |
| England League 1 | 2015/01/24 15:00 | Colchester v Leyton Orient | L | 2-0 |
| England League 1 | 2014/09/13 14:00 | Leyton Orient v Colchester | L | 0-2 |