[6] San Francisco FC 0-1 Veraguas CD [4] 2021-11-20 21:00
Stadium: Estadio Agustín Muquita Sánchez Round: 16
Head to Head
| Panama LPF | 2021/09/04 23:00 | Veraguas CD v San Francisco FC | L | 1-0 |
| Panama LPF | 2021/05/08 22:00 | Veraguas CD v San Francisco FC | L | 2-1 |
| Panama LPF | 2021/03/17 22:00 | San Francisco FC v Veraguas CD | L | 1-2 |