[4] FC Twente 3-0 FC Groningen [10] 2022-05-11 18:00
Stadium: Grolsch Veste Stadium Round: 33
Referee: Martin Van den Kerkhof Home Manager: Ron Jans Away Manager: Danny Buijs
Head to Head
| Netherlands Eredivisie | 2021/10/01 18:00 | FC Groningen v FC Twente | D | 1-1 |
| Netherlands Eredivisie | 2021/01/17 13:30 | FC Groningen v FC Twente | D | 2-2 |
| Netherlands Eredivisie | 2020/09/25 18:00 | FC Twente v FC Groningen | W | 3-1 |
| Netherlands Eredivisie | 2020/01/18 18:45 | FC Twente v FC Groningen | D | 0-0 |
| Netherlands Eredivisie | 2019/08/10 16:30 | FC Groningen v FC Twente | W | 1-3 |
| Netherlands Cup | 2018/09/27 16:30 | FC Groningen v FC Twente | W | 0-2 |
| Netherlands Eredivisie | 2018/03/04 15:45 | FC Twente v FC Groningen | D | 1-1 |
| Netherlands Eredivisie | 2017/09/24 12:30 | FC Groningen v FC Twente | L | 1-0 |
| Netherlands Eredivisie | 2017/05/14 12:30 | FC Twente v FC Groningen | L | 3-5 |
| Netherlands Eredivisie | 2016/08/21 10:30 | FC Groningen v FC Twente | W | 3-4 |
| Netherlands Eredivisie | 2016/02/27 17:30 | FC Twente v FC Groningen | W | 2-0 |
| Netherlands Cup | 2015/09/23 16:30 | FC Groningen v FC Twente | L | 2-1 |
| Netherlands Eredivisie | 2015/08/12 16:30 | FC Groningen v FC Twente | D | 1-1 |
| Netherlands Eredivisie | 2015/03/22 13:30 | FC Groningen v FC Twente | D | 2-2 |
| Netherlands Eredivisie | 2014/11/30 13:30 | FC Twente v FC Groningen | L | 1-2 |