[6] BUF Sabres 2-6 CAR Hurricanes [5] 2021-12-05 00:30
Stadium: PNC Arena
Home Manager: Rod Brind'Amour Away Manager: Don Granato
Head to Head
| NHL | 2019/11/15 00:00 | CAR Hurricanes v BUF Sabres | L | 5-4 |
| NHL | 2019/03/16 23:00 | BUF Sabres v CAR Hurricanes | L | 2-4 |
| NHL | 2019/02/08 00:00 | CAR Hurricanes v BUF Sabres | L | 6-5 |
| NHL | 2019/01/12 00:30 | BUF Sabres v CAR Hurricanes | L | 3-4 |
| NHL | 2017/12/24 00:00 | BUF Sabres v CAR Hurricanes | L | 2-4 |
| NHL | 2017/12/16 00:00 | CAR Hurricanes v BUF Sabres | L | 5-4 |
| NHL | 2017/11/19 00:00 | CAR Hurricanes v BUF Sabres | L | 3-1 |
| NHL Pre-Season | 2017/09/18 23:00 | CAR Hurricanes v BUF Sabres | L | 3-2 |
| NHL | 2017/01/14 00:30 | BUF Sabres v CAR Hurricanes | L | 2-5 |
| NHL | 2016/12/23 00:00 | CAR Hurricanes v BUF Sabres | L | 3-1 |
| NHL | 2016/12/18 00:00 | BUF Sabres v CAR Hurricanes | L | 1-2 |
| NHL Pre-Season | 2016/10/04 22:58 | CAR Hurricanes v BUF Sabres | W | 0-2 |