[4] Alexander Zverev 7-6,6-7,10-5 John Isner [22] 2021-09-25 18:50
Stadium: Center Court Round: 44 Ground: Hardcourt indoor
Head to Head
| Laver Cup | 2019/09/21 11:00 | Alexander Zverev v John Isner | 7-6,4-6,1-10 |
| ATP World Tour Finals | 2018/11/16 14:00 | Alexander Zverev v John Isner | 7-6,6-3 |
| Laver Cup | 2018/09/22 18:00 | Alexander Zverev v John Isner | 3-6,7-6,10-7 |
| ATP Madrid | 2018/05/11 20:00 | John Isner v Alexander Zverev | 4-6,5-7 |
| ATP Miami | 2018/04/01 17:00 | Alexander Zverev v John Isner | 7-6,4-6,4-6 |
| ATP Rome | 2017/05/20 13:00 | Alexander Zverev v John Isner | 6-4,6-7,6-1 |
| ATP Miami | 2017/03/27 20:40 | John Isner v Alexander Zverev | 7-6,6-7,6-7 |
| ATP Shanghai | 2016/10/10 07:10 | Alexander Zverev v John Isner | 6-4,6-2 |