[5] Sportivo Luqueno 0-1 Guairena FC [10] 2021-12-04 21:15
Stadium: Estadio Feliciano Caceres Round: 18
Referee: Juan Gabriel Benitez Home Manager: Badayco Maciel Away Manager: Troadio Daniel Duarte
Head to Head
| Paraguay Division Profesional | 2021/09/20 00:15 | Guairena FC v Sportivo Luqueno | W | 1-2 |
| Paraguay Division Profesional | 2021/04/03 22:15 | Guairena FC v Sportivo Luqueno | L | 3-0 |
| Paraguay Division Profesional | 2021/02/05 21:30 | Sportivo Luqueno v Guairena FC | W | 3-1 |
| Paraguay Division Profesional | 2020/12/11 21:30 | Guairena FC v Sportivo Luqueno | L | 1-0 |
| Paraguay Division Profesional | 2020/08/18 20:00 | Guairena FC v Sportivo Luqueno | W | 0-1 |
| Paraguay Division Profesional | 2020/01/31 21:00 | Sportivo Luqueno v Guairena FC | D | 1-1 |