Houston 20-35 Cincinnati 2021-12-04 21:00
Stadium: Nippert Stadium Round: 1
Home Manager: Luke Fickell Away Manager: Dana Holgorsen
Head to Head
| NCAAF | 2020/11/07 20:30 | Houston v Cincinnati | L | 10-38 |
| NCAAF | 2019/10/12 19:30 | Cincinnati v Houston | L | 38-23 |
| NCAAF | 2016/09/15 23:30 | Houston v Cincinnati | W | 40-16 |
| NCAAF | 2015/11/07 20:30 | Houston v Cincinnati | W | 33-30 |
| NCAAF | 2014/12/06 17:00 | Cincinnati v Houston | L | 38-31 |
| NCAAF | 2002/11/16 12:00 | Cincinnati v Houston | L | 47-14 |
| NCAAF | 2001/10/20 12:00 | Houston v Cincinnati | L | 28-29 |
| NCAAF | 2000/10/07 12:00 | Cincinnati v Houston | L | 48-31 |