[12] Atlas 1-0 Atletico San Luis [14] 2022-01-15 23:00
Stadium: Estadio Jalisco Round: 2
Referee: Brian Omar Gonzalez Veles Home Manager: Diego Cocca Away Manager: Marcelo Mendez
Head to Head
| Mexico Liga MX | 2021/10/25 00:00 | Atletico San Luis v Atlas | W | 2-6 |
| Mexico Liga MX | 2021/03/02 23:00 | Atlas v Atletico San Luis | W | 3-1 |
| Mexico Liga MX | 2020/08/10 00:00 | Atletico San Luis v Atlas | D | 1-1 |
| Mexico Liga MX | 2019/11/02 03:00 | Atlas v Atletico San Luis | L | 1-2 |