[14] Club America 2-3 Atletico San Luis [18] 2022-02-06 01:00
Stadium: Estadio Azteca Round: 4
Referee: Adonai Escobedo Gonzalez Home Manager: Santiago Hernan Solari Poggio Away Manager: Marcelo Mendez
Head to Head
| Mexico Liga MX | 2021/10/17 00:00 | Atletico San Luis v Club America | W | 0-1 |
| Mexico Liga MX | 2021/01/10 03:00 | Club America v Atletico San Luis | W | 2-1 |
| Mexico Liga MX | 2020/08/30 00:00 | Atletico San Luis v Club America | W | 1-2 |
| Mexico Liga MX | 2019/10/30 01:00 | Atletico San Luis v Club America | W | 0-1 |
| Mexico Cup | 2019/01/31 03:00 | Atletico San Luis v Club America | L | 2-0 |
| Mexico Cup | 2019/01/24 03:00 | Club America v Atletico San Luis | W | 1-0 |